Nick Verougstraete

CRIG member
Nick Verougstraete


Clinical biologist – Toxicology lab (Department of laboratory medicine, UZ Gent)
PhD researcher – Toxicology lab (Faculty of pharmaceutical sciences, UGent)
Principal investigators: prof. Alain Verstraete (MD, PhD) & prof. Christophe Stove (PhD)

 

Research focus

My research focuses on therapeutic drug monitoring (TDM) of anticancer drugs: tyrosine kinase inhibitors used for treatment of CML/AML/CLL and busulfan-fludarabine used in allogeneic hematopoietic stem cell transplantation. TDM of anticancer treatment is not yet routinely performed, although it offers a high potential to improve treatment outcome and minimize toxicity. In other words, it is vital for personalized cancer treatment. We develop analytical methods for the quantification of these drugs in regular plasma and in alternative samples, such as dried blood microsamples which enable (home) sampling by the patients themselves. Measured concentrations are correlated with clinical status of the patient, molecular response, presence of adverse effects,… The methods can also be used in clinical routine practice.
 

Key publications

  • Quantification of eight hematological tyrosine kinase inhibitors in both plasma and whole blood by a validated LC-MS/MS method. Talanta, 2021. (PMID: 33676691)
  • Barriers and opportunities for the clinical implementation of therapeutic drug monitoring in oncology. British journal of clinical pharmacology, 2021. (PMID: 32430968)
     

Contact & links

  • Lab address: Campus UZ Gent, Corneel Heymanslaan 10, 9000 Gent
  • Nick Verougstraete is interested to receive invitations for presentations or talks