dr. Lisette Van Hove (PhD)
Our team focusses on understanding the cellular and molecular crosstalk between keratinocytes- the epithelial cells of the skin- and their microenvironment in health and disease. During injury, fast repair mechanisms are critical to maintain the skin’s barrier function and we study how epidermal cells, fibroblasts and immune cells orchestrate inflammation and subsequent tissue regeneration. Wound repair can however predispose tissues to cancer initiation and we aim to identify novel molecular mechanisms through which inflammation, cell death and fibrosis modulate epidermal cells and impact on skin regeneration and neoplasia.
In my project we aim to analyse the role of Atg16L1, an essential component for the execution of autophagy, in skin homeostasis, inflammation and cancer development. Autophagy is a cellular recycling program that helps cells to cope with stress. Autophagy is often dysregulated during inflammatory diseases and has been shown to suppress various types of cancer, while promoting progression of others, in a tissue- and context-dependent manner. Polymorphisms in the Atg16L1 gene have been associated with psoriasis vulgaris, indicating that autophagy could critically mediate skin inflammation with possible implications for tumour biology.
- Master biochemie en biotechnologie, 2016, KU Leuven
- ’Epithelial HMGB1 delays skin wound healing and drives tumor initiation by priming neutrophils for NET formation’, Cell Reports, 2019 (PMID: 31775038)
- ‘Fibrotic enzymes modulate wound-induced skin tumorigenesis’, EMBO Reports – 2021 (PMID: 33780134)
- ‘Activation of fibroblasts in skin cancer’, Journal of Investigative Dermatology – 2021
- ‘OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity’, Nature Communications - 2021
- ‘OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis’, Cell Reports - 2020 (PMID: 32075762 )
- ‘Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation’, Cell Reports -2019 (PMID: 31775038)
Contact & links
- Lab address: VIB-UGent Center for Inflammation Research, Technologiepark 71, 9052 Gent-Zwijnaarde
- Keratinocyte microenvironment lab