prof. Tim Lammens (PhD)

CRIG member
Tim Lammens

Principal investigator – Lab for pediatric hematology-oncology, Ghent University Hospital, Ghent
Assistant professor (Faculty of Medicine and Health Sciences, UGent)
Laboratory supervisor – Lab for asparaginase monitoring, Ghent

 

Research focus

Our goal is to contribute to increase the cure rates of pediatric cancer and decrease the therapy-related late effects within survivors. 

We are keeping our focus on various pediatric cancer types i.e. pre-B ALL, JMML, AML and neuroblastoma. Our research key areas within the specific focus include: i) working on cancer predisposition by identifying new oncogenes and tumor suppressors and defining their mechanisms of action in families with multiple affected children and immunodeficient children which are prone to develop cancer; ii) preclinical evaluation of new treatments; iii) establishing strategies to develop highly specific personalized drug therapies, iv) offering real-time monitoring of therapeutic drug levels during treatment of childhood cancer, in order to ensure efficacy of therapy and identify genetic factors influencing toxicity. and vi) actively participating to a diverse array of clinical trials.

These studies are carried out by employing genome-wide screening techniques at the DNA level (array CGH, whole genome and candidate gene DNA sequencing) as well as at the RNA level (gene expression and microRNA profiling). In addition, we employ high- end flow sorting and single-cell transcriptomics. Therapeutic asparaginase-monitoring is performed using spectrophotometry, with a quality assurance system in place. In addition, biobanking within national and international clinical trials is a core activity.

Importantly, the optimal translation of the fundamental and applied research into children benefit (short-and long-term) is a major aspect throughout all our research lines
 

Biography

SCIENTIFIC DEGREES

  •  2003: Msc. Industrial engineering biochemistry
  •  2004: Msc. Molecular biotechnology
  •  2009: PhD molecular biotechnology

PROFESSIONAL CAREER

  •  2004-2009: PhD student, Ghent University
  •  2009-present: postdoctoral fellow, Department of Pediatric Hematology-Oncology, Ghent University
  •  2015-present: assistant professor, Ghent University

MEMBERSHIPS

  •  Member of BSPHO, SIOP, BHS, EWOG-MDS, EORTC-CLG, I-BFM AML, IntReALL and SIOPE Host Genome working groups
  •  Member of management committee Cost Action CA16223
  •  Member of advisory board TMB RAPID

 

Research team

  • prof. Tim Lammens – principal investigator
  • dr. Araceli Diez Fraile – post-doctoral fellow
  • Barbara Depreter – doctoral fellow
  • Charlotte Derpoorter – doctoral fellow
  • Mattias Hofmans – doctoral fellow
  • Inge D`Hont - technician
  • Martijn de Jong - technician
  • Larissa Deneweth - technician
  • Eva Terras - technician
  • Katrien Vandemeulebroecke - technician
     

Key publications

  • `TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment`. Haematologica, 2019. (PMID: 31371409)
  • `Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients`. JCI Insight, 2018. (PMID: 30518699)
  • `Pinpointing a potential role for CLEC12B in cancer predisposition through familial exome sequencing`. Pediatric Blood Cancer, 2019. (PMID: 30350915)
  • `A novel l-asparaginase with low l-glutaminase coactivity is highly efficacious against both T- and B-cell acute lymphoblastic leukemias in vivo`. Cancer Research, 2018. (PMID: 29343523)
  • `Cancer-related mRNA expression analysis using a novel flow cytometry-based assay`. Cytometry B Clinical Cytometry, 2018. (PMID: 28980766)
  • `Unique long non-coding RNA expression signature in ETV6/RUNX1-driven B-cell precursor acute lymphoblastic leukemia`. Oncotarget, 2016. (PMID : 27650541)
  • `LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia`. Blood, 2016. (PMID: 26712910)
  • `CD200/BTLA deletions in pediatric precursor B-cell acute lymphoblastic leukemia treated according to the EORTC-CLG 58951 protocol`. Haematologica, 2015. (PMID: 26137961)
     

Contact & links