prof. Charlotte Debbaut (PhD)

CRIG member
Charlotte Debbaut


Principal investigator - BioMMeda
Assistant professor, IbiTech-bioMMeda

 

Research focus

IBiTech-bioMMeda is a research group mainly composed of researchers with a background in (biomedical) engineering. Our core expertise is the computational and experimental study of the mechanics of biofluids, soft tissues and medical devices. Within bioMMeda, my focus is on the use of computational biomechanics as a tool for personalised medicine in two main research areas: cancer and minimally invasive procedures. Our cancer-related research includes topics such as locoregional drug delivery. In this respect, we are studying the mass transport of drugs in order to optimize and personalize the drug delivery during transarterial therapies for liver cancer and during intraperitoneal chemotherapy for peritoneal carcinomatosis. Currently, we also work on the development of planning tools in support of minimally invasive interventions, such as robot-assisted partial nephrectomy procedures for kidney cancer and catheter-guided interventions in the brain. In addition, we investigate the mass transport in the lymphatic system in order to better understand and treat lymphedema (potential side effect of breast cancer surgery and radiation therapy).
 

Biography

Prof. dr. ir. Charlotte Debbaut received the degree of “Bachelor of Science in the Engineering Sciences: mechanics-electrotechnics” in 2007 (Ghent University) and the degree of interuniversity “Master of Science in Biomedical Engineering” in 2009 (Ghent University and Vrije Universiteit Brussel). In 2013, she obtained her PhD in Biomedical Engineering entitled “Multi-level Modelling of Hepatic Perfusion in Support of Liver Transplantation Strategies” at Ghent University. Since 2013, she continued her research as a postdoctoral assistant. In 2015, she became assistant professor in biofluids and artificial organs (10%). Since 2019, she became full time assistant professor in computational biomechanics at the bioMMeda research group (Biofluid, Tissue and Solid Mechanics for Medical Applications), UGent. 
With her expertise on biofluid mechanics, her research mainly focuses on modelling organ perfusion (e.g. kidney, liver) in the context of transplantation, pathologies and therapies, as well as modelling mass transport phenomena in the context of targeted or locoregional drug delivery (e.g. transarterial therapies for liver cancer, intraperitoneal chemotherapy) and artificial organs.
 

Research team

  • Hooman Salavati - doctoral fellow
  • Tim Bomberna - doctoral fellow
  • Mohammad Rahimi Gorji - doctoral fellow
     

Key publications

  • Charlotte Debbaut, Diethard Monbaliu, Christophe Casteleyn, Pieter Cornillie, Denis Van Loo, Bert Masschaele, Jacques Pirenne, Paul Simoens, Luc Van Hoorebeke, and Patrick Segers. From Vascular Corrosion Cast to Electrical Analog Model for the Study of Human Liver Hemodynamics and Perfusion. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 58(1):25-35, 2011.
  • Debbaut Charlotte, Vierendeels Jan, Casteleyn Christophe, Cornillie Pieter, Van Loo Denis, Simoens Paul, Van Hoorebeke Luc, Monbaliu Diethard and Segers Patrick. Perfusion Characteristics of the Human Hepatic Microcirculation Based on Three-dimensional Reconstructions and Computational Fluid Dynamic Analysis. JOURNAL OF BIOMECHANICAL ENGINEERING 134(1):011003, 2012.
  • Charlotte Debbaut, David De Wilde, Christophe Casteleyn, Pieter Cornillie, Denis Van Loo, Luc Van Hoorebeke, Diethard Monbaliu, Ye-Dong Fan, and Patrick Segers. Modeling the Impact of Partial Hepatectomy on the Hepatic Hemodynamics Using a Rat Model. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 59(12):3293–3303, 2012.
  • Charlotte Debbaut, Patrick Segers, Pieter Cornillie, Christophe Casteleyn, Manuel Dierick, Wim Laleman, and Diethard Monbaliu. Analyzing the Human Liver Vascular Architecture by Combining Vascular Corrosion Casting and Micro-CT Scanning: a Feasibility Study. JOURNAL OF ANATOMY 224(4):509–517, 2014.
  • Charlotte Debbaut, Jan Vierendeels, Jennifer H Siggers, Rodolfo Repetto, Diethard Monbaliu, and Patrick Segers. A 3D Porous Media Liver Lobule Model: the Importance of Vascular Septa and Anisotropic Permeability for Homogeneous Perfusion. COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING 17(12):1295–1310, 2014.
  • Charlotte Debbaut, Diethard Monbaliu, and Patrick Segers. Engineering Point of View on Liver Transplantation Strategies: Multi-Level Modeling of Hepatic Perfusion. TRANSPLANTATION PROCEEDINGS 46(9):3143–3146, 2014.
  • Margo Steuperaert, Giuseppe Falvo D’Urso Labate, Charlotte Debbaut, Olivier De Wever, Christian Vanhove, Wim Ceelen, and Patrick Segers. Mathematical Modeling of Intraperitoneal Drug Delivery : Simulation of Drug Distribution in a Single Tumor Nodule. DRUG DELIVERY 24 (1): 491–501, 2017.
  • Geert Peeters, Charlotte Debbaut, Wim Laleman, Diethard Monbaliu, Ingrid Vander Elst, Jan R. Detrez, Tim Vandecasteele, Thomas De Schryver, Luc Van Hoorebeke, Kasper Favere, Jonas Verbeke, Patrick Segers, Pieter Cornillie, and Winnok De Vos. A Multilevel Framework to Reconstruct Anatomical 3D Models of the Hepatic Vasculature in Rat Livers. JOURNAL OF ANATOMY 230 (3): 471–483, 2017.
  • Chloe Audebert, Geert Peeters, Patrick Segers, Wim Laleman, Diethard Monbaliu, Hannelie Korf, Jonel Trebicka, Irene Vignon-Clementel, and Charlotte Debbaut. Closed-loop Lumped Parameter Modelling of Hemodynamics During Cirrhogenesis in Rats. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 65 (10): 2311-2322, 2018.
  • Geert Peeters, Charlotte Debbaut, Adrian Friebel, Pieter Cornillie, Winnok De Vos, Kasper Favere, Ingrid Vander Elst, Tim Vandecasteele, Tim Johann, Luc Van Hoorebeke, Diethard Monbaliu, Dirk Drasdo, Stefan Hoehme, Wim Laleman, and Patrick Segers. Quantitative Analysis of Hepatic Macro- and Microvascular Alterations During Cirrhogenesis in the Rat. JOURNAL OF ANATOMY 232 (3): 485–496, 2018.
  • Margo Steuperaert, Charlotte Debbaut, Charlotte Carlier, Olivier De Wever, Benedicte Descamps, Christian Van Hove, Wim Ceelen, and Patrick Segers. A 3D CFD model of the interstitial fluid pressure and drug distribution in heterogeneous tumor nodules during intraperitoneal chemotherapy. DRUG DELIVERY, 26:1, 404-415, 2019.
     

Contact & links

  • IBiTech - bioMMeda, Department of Electronics and Information Systems, Ghent University Campus UZ - Blok B - Ingang 36, Corneel Heymanslaan 10, 9000 Gent, Belgium
  • Biommeda