'Pioneer factor-enabled chromatin compartments support prognostic gene expression programs in cohesin-destabilised lung cancer' - Lecture

Lecture by Prof. Stefan Prekovic (UMC Utrecht Center for Molecular Medicine).

The team of Prof. Prekovic focuses on chromatin-related factors and their effects on cellular phenotypes, employing a range of state-of-the-art omics techniques. The objective is to uncover targetable pathways that can effectively eliminate cancer cells.

The focus of our research is, thus, on the relationship of transcription factors and their target-genes and how this can generate diverse cellular states and therefore contribute to cancer cell heterogeneity. Particularly, our research lines aim to shed light on (1) the reprogramming of chromatin-related factors in relation to cell identity; (2) transcription factor structure-function in locus-specific gene regulation and genome biology; and (3) cancer cell heterogeneity on single-cell level. We believe that through exploration of these faucets of transcription factor biology we will be able to uncover novel biomarkers and potential targetable routes to treat cancer.