dr. Lieselot Y. Hemeryck (PhD)

CRIG member
Lieselot Y. Hemeryck

Post-doctoral fellow - Lab of Chemical Analysis, Department of Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine (UGent)
Assistant - Lab of Chemical Analysis, Department of Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine (UGent)
Principal investigator: prof. Lynn Vanhaecke (PhD)

 

Research focus

For many conditions linked to poor gut health, and in particular colorectal cancer, personalized preventive strategies and diagnostic, prognostic or predictive biomarkers of disease are currently lacking. It is our belief that unravelling the molecular basis by which the exposome (diet, gut microbiome, etc.) impacts the human metabolome may address this hurdle. Therefore our research aims to (1) develop a true molecular high-resolution mass spectometry based metabolomics platform (including both polar to medium apolar metabolites, lipidomics and DNA adductomics) to discriminate the metabolic phenotypes of healthy vs. diseased individuals (human and animal studies), and (2) unravel the impact of the exposome on host metabolome (e.g. impact of red meat consumption on digestive metabolome in relation to CRC promotion). In this context, methodologies for the most frequently reported specimens that allow exploring systemic alterations of metabolites in humans (i.e. tissue, blood and urine) are available at LCA. In addition, a novel methodology for polar metabolites in feces was successfully developed and validated in recent years (Vanden Bussche et al., 2015), as well as a new methodology for fecal lipidomics (Van Meulebroek et al., 2017). Indeed, in relation to gut health, feces comprises a rich source of information that allows assessment of the complex interactions between the gut microbiota and the host and as such reflects the dietary input and biochemical events that have occurred during digestion best. Additionally, methodologies for DNA adductomics, a recently breached branch of metabolomics, have been successfully optimized and implemented (o.a. Hemeryck et al. 2015). The application of the above mentioned methodologies for the discovery of reliable and robust biomarkers to enable early diagnosis, screening, surveillance, and primary prevention of the disease, through e.g. dietary recommendations, belongs to our current research objectives. 
 

Biography

Lieselot Hemeryck was born in 1988 in Ostend, Belgium. In 2012 she obtained a Master in Veterinary Medicine with great distinction and was awarded with the prize for the best Master Thesis in Veterinary Medicine, option 'Research'. Shortly after, she was appointed as a teaching assistant at the department of Veterinary Public Health and Food Safety at the faculty of Veterinary Medicine. Lieselot Hemeryck’s PhD research focused on the use of DNA adductomics to unravel the proposed causal link between red meat consumption and the development of colorectal cancer, and was recently awarded with the award for scientific research in Veterinary Medicine by the Belgian Royal Academy of Medicine (KAGB). Dr. Hemeryck is currently employed as doctor-assistant and postdoctoral researcher at the Lab of Chemical Analysis.
 

Key publications

  • 'O⁶-carboxymethylguanine DNA adduct formation and lipid peroxidation upon in vitro gastrointestinal digestion of haem-rich meat.' Molecular Nutrition and Food Research, 2014. (PMID: 24990219)
  • 'Increased oxidative and nitrosative reactions during digestion could contribute to the association between well-done red meat consumption and colorectal cancer.' Food Chemistry, 2015. (PMID: 25976994)
  • 'High resolution mass spectrometry based profiling of diet-related deoxyribonucleic acid adducts.' Analytica Chimica Acta, 2015. (PMID: 26388482)
  • 'Diet-related DNA adduct formation in relation to carcinogenesis.' Nutrition Reviews, 2016. (PMID: 27330144)
  • 'Mass Spectrometric Mapping of the DNA Adductome as a Means to Study Genotoxin Exposure, Metabolism, and Effect.' Analytical Chemistry, 2016. (PMID: 27362284)
  • ‘In vitro DNA adduct profiling to mechanistically link red meat consumption to colon cancer promotion.’ Toxicology Research, 2016. (PMID: 30090439)
  • ‘DNA adductomics to study the genotoxic effects of red meat consumption with and without added animal fat in rats.’ Food Chemistry, 2017. (PMID: 28407925)
  • ‘DNA adduct profiling of in vitro colonic meat digests to map red vs. white meat genotoxicity.’ Food and Chemical Toxicology, 2018. (PMID: 29458163)
  • ‘Untargeted metabolomics of colonic digests reveals kynurenine pathway metabolites, dityrosine and 3-dehydroxycarnitine as red versus white meat discriminating metabolites.’ Scientific Reports, 2018. (PMID: 28195169)
  • ‘A validated multi-matrix platform for metabolomic fingerprinting of human urine, feces and plasma using ultra-high performance liquid-chromatography coupled to hybrid orbitrap high-resolution mass spectrometry.’ Analytica Chimica Acta, 2018. (PMID: 30172316)
  • ‘Nutrimetabolomics : an integrative action for metabolomic analyses in human nutritional studies (2018) Molecular Nutrition and Food Research, 2018. (PMID: 30176196)
     

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