Vacancy: PhD and postdoc positions for research projects on leukemia (CRIG, UGent)

The Ntziachristos laboratory is looking for PhD students and/or a postdoc researchers.

This lab studies the mechanistic aspects of oncogenesis with an emphasis on transcriptional and epigenetic regulation of acute leukemia. They focus on how oncogenes interact with each other and with epigenetic modulators to influence gene expression programs as well as how their function is related to tri-dimensional (3D) structure of the nucleus and other biological aspects of cancer cells, like metabolism. Recent studies from this group focus on how active deubiquitination controls aspects of oncogenesis, including transcription factors or splicing, and ultimately leads to drug resistance in leukemia. To address these questions, they use high-throughput molecular and cell biology techniques like RNA-Seq, ChIP-Seq, 4C-Seq and HiC, fluorescent in situ hybridization, biochemical analysis e.t.c., in cell lines and primary cells of human origin and tissues of mouse models of disease. In addition to understanding cancer biology these finding help them design and test targeted therapies in preclinical models of leukemia.