Zenzi De Vos
Research assistant - Department of Diagnostic Sciences (UGent)
Principal investigator: prof. Georges Leclercq (PhD)
Immunotherapy is increasingly used as a means to fight cancer. Based on the proven cytolytic capacity of natural killer cells (NK cells) against tumor cells, there is increased interest to use NK cells in adoptive cell therapy in cancer patients. NK cell development and maturation are orchestrated by a network of transcription factors, of which, contrary to mice, knowledge is rudimentary in human.
Our research team focuses on the role of transcription factors in human NK cell differentiation and function. Therefore, umbilical cord blood-derived hematopoietic progenitor cells, in which a particular transcription factor is either overexpressed or downregulated, are kinetically analyzed in an in vitro NK cell differentiation model. The obtained insights can either be of interest for the development of novel NK cell-based immunotherapies or for the improvement of existing therapies.
Contact & links
- Ghent University, Department of Diagnostic Sciences, MRB2, entrance 38, first floor, Corneel Heymanslaan 10, 9000 Ghent, Belgium