Lisette Van Hove
Our team focusses on understanding the cellular and molecular crosstalk between keratinocytes- the epithelial cells of the skin- and their microenvironment in health and disease. During injury, fast repair mechanisms are critical to maintain the skin’s barrier function and we study how epidermal cells, fibroblasts and immune cells orchestrate inflammation and subsequent tissue regeneration. Wound repair can however predispose tissues to cancer initiation and we aim to identify novel molecular mechanisms through which inflammation, cell death and fibrosis modulate epidermal cells and impact on skin regeneration and neoplasia.
I aim to characterize the inflammatory, fibrotic and tumor-promoting activities of skin fibroblasts. Fibroblasts produce collagen and extracellular matrix and have the potential to suppress epithelial growth and cancer. However, following injury or in certain types of cancer, fibroblasts are activated to promote epithelial proliferation. I aim to identify molecules that tip the balance between the epithelial growth-inhibitory and -promoting roles of skin fibroblasts. Furthermore I study the role of autophagy in keratinocytes in inflammation and cancer.
- Master biochemie en biotechnologie, 2016, KU Leuven
- ’Epithelial HMGB1 delays skin wound healing and drives tumor initiation by priming neutrophils for NET formation’, Cell Reports, 2019 (PMID: 31775038)
Contact & links
- Lab address: VIB-UGent Center for Inflammation Research, Technologiepark 71, 9052 Gent-Zwijnaarde
- Keratinocyte microenvironment lab