Edith De Bruycker
PhD student – Center for medical biotechnology (VIB-UGent)
Principal Investigator: prof. Sven Eyckerman (PhD)
Long non-coding RNAs (LncRNAs) have gained widespread attention as a new layer in biological processes and disease development. It is of great value to define the interaction partners of cancer-specific lncRNAs to determine their function and/or pathway. The identification enables the possibility to explore lncRNAs as a novel class of potential biomarkers as well as new clinical targets.
Despite the wide range of technologies to define potential (protein) interaction partners, many of these technologies tend to harbor a few drawbacks. Therefore, our team focuses on the development of alternative yet complementary techniques.
A new exciting field has arisen in which RNA bound proteins introduce nucleation resulting in liquid-liquid phase separation (llps; PML nuclear bodies, stress granules). Under certain (pathological) circumstances, membraneless compartmentalization- harboring complex spatiotemporal regulation of biochemical processes (for example DDR)- is disturbed. We would like to investigate how to manipulate and/or disrupt phase separation to explore a new therapeutic loophole to target cancer and/or neurodegenerative diseases.
Contact & links
- Lab address: Albert Baertsoenkaai 3 Gent 9000