dr. Ondrej Sedlacek (PhD)
postdoctoral researcher - Supramolecular Chemistry Group (Faculty of Sciences, UGent)
(PI: prof. Richard Hoogenboom)
My research focuses on the synthesis of new drug delivery systems based on the polymer-drug conjugates. These conjugates are accumulated in the cancer tissue through the enhanced permeation and retention (EPR) effect. In the tumor environment, the anticancer drug (e.g., doxorubicin) is selectively released from its polymer carrier in its therapeutically active form, resulting in substantial tumor growth inhibition. The effectivity of these systems may be further enhanced by attachment of specific targeting units (peptides, antibodies etc.).
Ondrej Sedlacek received his Ph.D. degree from the Institute of Macromolecular Chemistry of the Academy of Sciences of the Czech Republic in 2015 in the field of polymeric drug delivery systems. After the postdoctoral research position at National Institute for Materials Science, Tsukuba (Japan), he joined the Supramolecular Chemistry Group at Faculty of Sciences, UGent, as FWO Pegasus Marie Sklodowska-Curie postdoctoral fellow. His research interests include biocompatible biodegradable polymers and stimuli-responsive supramolecular polymer systems as drug and radionuclide carriers.
- Radiolabelled Polymeric Materials for Imaging and Treatment of Cancer: Quo Vadis? Advanced Healthcare Materials 2017 (DOI: 10.1002/adhm.201601115)
- Multistage-targeted pH-responsive polymer conjugate of Auger electron emitter: Optimized design and in vivo activity. European Journal of Pharmaceutical Sciences 2014 (DOI: 10.1016/j.ejps.2014.07.012)
- Polymer conjugates of acridine-type anticancer drugs with pH-controlled activation. Bioorganic & Medicinal Chemistry 2012 (10.1016/j.bmc.2012.05.007)
- Ellipticine-Aimed Polymer-Conjugated Auger Electron Emitter: Multistage Organelle Targeting Approach. Bioconjugate Chemistry 2011 (DOI: 10.1021/bc200064v)
Contact & links
- Google Scholar
- lab address: Department of Organic and Macromolecular Chemistry, Supramolecular Chemistry Group, Center of Macromolecular Chemistry (CMaC), Faculty of Sciences, Krijgslaan 281, Building S4, B-9000 Ghent, Belgium