dr. Marthe De Boevre (PhD)

CRIG member
Marthe De Boevre

Postdoctoral assistant - Laboratory of Foood Analysis, Faculty of Pharamceutical Sciences (UGent)
Principal investigator: prof. Sarah De Saeger (PhD)

Research focus

Foods may be contaminated by microorganisms (bacteria, fungi) during cultivation, harvest, storage, processing, distribution, or preparation. Under certain conditions, some fungi that contaminate crops may produce toxic components, such as mycotoxins. Many different classes of mycotoxins (aflatoxins, trichothecenes, fumonisins, etc.) may be produced by a range of fungi. Contaminated crops may be consumed directly, or indirectly, through animal products (meat, milk, etc.) raised on contaminated feed. Mycotoxins can cause a wide range of toxic effects in humans, from reportedly inducing carcinogenesis or DNA damage, to targeting specific organs, like the kidney, liver, or intestines. Although the health effects of some specific mycotoxins are already well investigated (like aflatoxins), the effect of chronically consuming multiple mycotoxins has not been researched. Therefore, this study aims to investigate health effects, particularly cancer risk, due to long-term consumption of multiple mycotoxins. The study will use one of the largest cohorts in Europe, including half a million subjects from ten countries, namely The European Prospective Investigation into Cancer and Nutrition (EPIC) study cohort. Participants’ dietary mycotoxin exposure will be investigated via dietary questionnaires and blood samples, collected at baseline of the EPIC study, which started in 1992, and using multi-mycotoxin levels in foods obtained via EFSA and its member states. Intakes among cancer cases will be compared against non-cancer cases, with a main focus on colorectal and hepatocellular cancers. These analyses should tell us more about the relationship between intake of multiple mycotoxins and cancer risk.

Biography

  • Master in Pharmaceutical Sciences, 2009, Ghent University
  • Doctor in Pharmaceutical Sciences, 2013, Ghent University (Chemical risks related to food and feed containing masked Fusarium mycotoxins)
  • Postdoctoral assistant (2013-to date): coordinator of research line 'mycotoxins and public health' within the Laboratory of Food Analysis

Key publications

  • Dietary mycotoxins, co-exposure, and carcinogenesis in humans: Short review. Mutation Research/Reviews in Mutation Research, 2015. (PMID: 26596546)

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