dr. Björn De Samber (PhD)

CRIG member
Björn De Samber


post-doctoral researcher - X-ray Microspectroscopy and Imaging group (XMI), Department of Analytical Chemistry, Faculty of Sciences, Ghent University
(PI: prof. Laszlo Vincze)
 

Research focus

Our research group is specialized at synchrotron radiation X-ray spectroscopy (SR nano-XRF). This technique allows to visualize trace level elemental distributions at microscopic (tissues) and nanoscopic (cells) in a non-destructive manner. The technique is multi-elemental and can image P, S, Cl, K, Ca, Mn, Fe, Ni, Cu, Zn, Se, Br but also exogenous elements such as Pt, Ru, Au, Ag. Besides, also information on the local chemical environment of the element can be obtained using X-ray absorption spectrosocopy (XAS). 

Our group performs micro and nanoscopic XRF/XANES measurements at synchrotron facilities, such as the European Synchrotron Radiation Facility (ESRF) in Grenoble, France and PETRAIII, Hamburg, Germany.
 

Key publications

  • Nanoscopic tumor tissue distribution of platinum after intraperitoneal administration in a xenograft model of ovarian cancer. Pharm Biomed Anal. 2016 Nov 30;131:256-262. doi: 10.1016/j.jpba.2016.09.004. Epub 2016 Sep 3.
  • Assessment of Ovarian Cancer Tumors Treated with Intraperitoneal Cisplatin Therapy by Nanoscopic X-ray Fluorescence Imaging. Sci Rep. 2016; 6: 29999. Published online 2016 Jul 21. doi:  10.1038/srep29999. PMCID: PMC4956760
  • Evaluation of confocal µ-XRF and ICP-MS for studying the pharmacodynamical properties of intraperitoneal chemohyperthermia with Oxaliplatin. Björn De Samber UGent, Veerle Van Lierde, W BOUQUET, W CEELEN, A HEYSE, Laszlo Vincze UGent, G FALKENBERG and Frank Vanhaecke UGent (2008) Desy Annual Report 2007. p.1477-1478

 

 

Contact & links