RRM2 is a potential synthetic lethal target in cancer cells. RRM2 is affected by copy number alterations including focal amplifications in neuroblastoma.
In my project I investigate the role of RRM2 as so-called replicative stress resistor and novel druggable target in neuroblastoma.
In addition, I'm also investigating upstream regulatory processes controlling RRM2 expression levels including the novel BIO-ID approach in collaboration with the Eyckerman lab.
Contact & links
- Lab address: Center for Medical Genetics Ghent (CMGG), Medical Research Building 1 (MRB1), 2nd floor, entrance 34, campus UZ Gent, Corneel Heymanslaan 10, 9000 Ghent, Belgium
- Speleman lab
- Center for Medical Genetics Ghent
- Carolina Nunes is interested to receive invitations for presentations or talks