T-cell acute lymphoblastic leukemia (T-ALL) is a hematological cancer caused by the oncogenetic transformation of developing thymocytes.
Despite improvements in survival, the treatments are associated with severe toxicities and the prognosis of patients with relapsed and refractory T-ALL remains poor.
I have conducted a detailed investigatation of long noncoding RNAs in a large cohort of T-ALL primary samples and also investigated the TLX1 oncogene driven lncRNAome.
I'm further studying the role of G2E3, a ubiquitin ligase, as replicative stress resistor in T-ALL and neuroblastoma.
Finally, I'm involved in optimizing single cell RNA sequencing to identify heterogeneity in cancer and in therapy responses.
I got the opportunity to talk about my doctoral research at OncoPoint 2016 (Ghent), fTales 2016 (Ghent), fTales 2017 (leuven) and the T-ALL workshop 2017 (Leuven).
- Verboom et al., A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing. Haematologica. 2018 ;haematol.2018.190587