Karen Verboom

CRIG member
Karen Verboom


Doctoral fellow - Lab for paediatric oncogenomics, Center for Medical Genetics (UGent)
Doctoral fellow - Lab for functional cancer genomics and applied bioinformatics, Center for Medical Genetics (UGent)
Principal investigators: prof. Jo Vandesompele (PhD) & prof. Frank Speleman (PhD)

Research focus

T-cell acute lymphoblastic leukemia (T-ALL) is a hematological cancer caused by the oncogenetic transformation of developing thymocytes. 
Despite improvements in survival, the treatments are associated with severe toxicities and the prognosis of patients with relapsed and refractory T-ALL remains poor. 
I have conducted a detailed investigatation of long noncoding RNAs in a large cohort of T-ALL primary samples and also investigated the TLX1 oncogene driven lncRNAome. 
I'm further studying the role of G2E3, a ubiquitin ligase, as replicative stress resistor in T-ALL and neuroblastoma. 
Finally, I'm involved in optimizing single cell RNA sequencing to identify heterogeneity in cancer and in therapy responses.
 

Biography

I obtained a Master in Biomedical Sciences with a major in Genetics (UGent, 2015). I immediately became a full-time doctoral fellow (BOF) at the lab of Frank Speleman and Jo Vandesompele.

I got the opportunity to talk about my doctoral research at OncoPoint 2016 (Ghent), fTales 2016 (Ghent), fTales 2017 (leuven) and the T-ALL workshop 2017 (Leuven).
 

Key publications

  • Verboom et al., A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing. Haematologica. 2018 ;haematol.2018.190587
     

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